Premium
Non‐Hodgkin's lymphoma, leukemia, and exposures in agriculture: Results from the Italian multicenter case‐control study
Author(s) -
Miligi Lucia,
Costantini Adele Seniori,
Bolejack Vanessa,
Veraldi Angela,
Benvenuti Alessandra,
Nanni Oriana,
Ramazzotti Valerio,
Tumino Rosario,
Stagnaro Emanuele,
Rodella Stefania,
Fontana Arabella,
Vindigni Carla,
Vineis Paolo
Publication year - 2003
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.10289
Subject(s) - medicine , pesticide , leukemia , lymphoma , etiology , case control study , environmental health , population , occupational exposure , toxicology , risk factor , biology , agronomy
Background The etiology of non‐Hodgkin's lymphoma (NHL) and leukemia is still largely unknown, but exposure to chemicals, in particular pesticides, has been suggested to be a risk factor. Methods A large population‐based case‐control study was conducted in Italy with the aim of investigating the associations between pesticide exposure and NHL, and solvents and leukemia. Data presented in this article refer to 1,575 interviewed cases and 1,232 controls in the nine agricultural study areas. Results Exposure to nitro‐derivatives and phenylimides among fungicides, hydrocarbon derivatives and insecticide oils among insecticides, and the herbicide amides are the chemical classes observed to be associated with the pathologies under investigation. Conclusions The results of the case‐control study suggest an increased risk for NHL and leukemia, and some chemical classes of pesticides, although few are statistically significant and some are based on few exposed cases. The results also show that men and women experience both similar and different risks for the same environmental agricultural exposures. Am. J. Ind. Med. 44:627–636, 2003. © 2003 Wiley‐Liss, Inc.