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Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case‐control study in Arnsberg, Germany
Author(s) -
Brüning Thomas,
Pesch Beate,
Wiesenhütter Bernd,
Rabstein Sylvia,
Lammert Marga,
Baumüller Axel,
Bolt Hermann M.
Publication year - 2003
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.10185
Subject(s) - medicine , odds ratio , confidence interval , case control study , risk factor , trichloroethylene , occupational medicine , epidemiology , occupational exposure , logistic regression , environmental health , chemistry , environmental chemistry
Background German studies of high exposure prevalence have been debated on the renal carcinogenicity of trichloroethylene (TRI). Methods A consecutive hospital‐based case‐control study with 134 renal cell cancer (RCC) cases and 401 controls was conducted to reevaluate the risk of TRI in this region which were estimated in a previous study. Exposure was self‐assessed to compare these studies. Additionally, the job history was analyzed, using expert‐based exposure information. Results The logistic regression results, adjusted for age, gender, and smoking, confirmed a TRI‐related RCC risk in this region. Using the database CAREX for a comparison of industries with and without TRI exposure, a significant excess risk was estimated for the longest held job in TRI‐exposing industries (odds ratio (OR) 1.80, 95% confidence interval (CI) 1.01–3.20). Any exposure in “metal degreasing” was a RCC risk factor (OR 5.57, 95% CI 2.33–13.32). Self‐reported narcotic symptoms, indicative of peak exposures, were associated with an excess risk (OR 3.71, 95% CI 1.80–7.54). Conclusions The study supports the human nephrocarcinogenicity of trichloroethylene. Am. J. Ind. Med. 43:274–285, 2003. © 2003 Wiley‐Liss, Inc.