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Association between bone lead concentration and blood pressure among young adults
Author(s) -
Gerr Fredric,
Letz Richard,
Stokes Lynette,
Chettle David,
McNeill Fiona,
Kaye Wendy
Publication year - 2002
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.10096
Subject(s) - medicine , lead (geology) , environmental health , blood pressure , lead exposure , occupational exposure , physiology , cats , geomorphology , geology
Background Occupational and environmental exposure to lead has been examined for its effect on blood pressure (BP) in adults with varying results. The present analyses assessed the association between bone lead concentration and BP in early adult life in persons exposed during childhood. Methods Study participants included young adult members of two cohorts with different past histories of lead exposure. Lead exposure was assessed using noninvasive K‐X‐ray fluorescence spectroscopy to quantify bone lead concentration, an index of long‐term lead exposure superior to current blood lead concentration. Systolic and diastolic BP measurements were obtained using conventional clinical methods. Multiple linear regression models were constructed to allow for control of covariates of BP identified a priori. Results Analyses were performed on 508 participants. While controlling for potential confounders, systolic BP was 4.3 mm Hg greater among members of the highest of four bone lead concentration groups (> 10 μgPb/g bone) when compared with the lowest bone lead concentration group (< 1 μgPb/g bone; P = 0.004), and diastolic BP was 2.8 mm Hg greater among members of the highest bone lead concentration group when compared with the lowest bone lead concentration group ( P = 0.03). Conclusions These results suggest that substantial lead exposure during childhood can increase BP during young adulthood. Am. J. Ind. Med. 42:98–106, 2002. © 2002 Wiley‐Liss, Inc.