Premium
Plasma marker for systemic inflammation is increased in Mexican Tarahumara following ultra‐distance running
Author(s) -
Skottrup Peter Durand,
Kallemose Thomas,
Espino Diana,
InfanteRamirez Rocio,
Brage Soren,
Terzic Dijana,
Goetze Jens Peter,
Kjaergaard Jesper,
Christensen Dirk Lund
Publication year - 2020
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.23501
Subject(s) - supar , medicine , biomarker , inflammation , glycated hemoglobin , plasminogen activator , c reactive protein , systemic inflammation , anthropometry , blood pressure , endocrinology , gastroenterology , urokinase receptor , biology , type 2 diabetes , diabetes mellitus , biochemistry
Objectives Previous studies have suggested that acute exercise‐induced cardiac and kidney damage following ultra‐distance running is low in Mexican Tarahumara even though C‐reactive protein (CRP) remained elevated 24 hours post‐race. We aimed to study if the plasma biomarker, soluble urokinase‐type plasminogen activator receptor (suPAR), could replace or complement CRP as a systemic inflammation biomarker in Tarahumara men and women following ultra‐distance running. Methods Plasma samples were collected pre‐race and at three to six different time points post‐race in Mexican Tarahumara competing in three independent ultramarathons; men running 78 km ( GroupI , n = 9), women running 52 km ( GroupII , n = 3), and men running 63 km ( GroupIII , n = 10). Baseline anthropometry, blood pressure, glycated hemoglobin, and hemoglobin were measured, aerobic fitness was estimated by submaximal step test, absolute and relative running intensity assessed using combined heart rate and accelerometry. Plasma was collected pre‐ and post‐race to analyze concentrations of suPAR, and—for women only—a panel of inflammatory, cardiac and kidney plasma biomarkers. Mixed‐effect models were used to evaluate the effect of ultramarathon running on plasma suPAR concentrations. Results Compared to pre‐race values, suPAR was significantly elevated in plasma <5 minutes after the three ultramarathon races (70%‐109% increase of the mean for the three groups). Furthermore, plasma suPAR remained significantly elevated up to 6 hours post‐race for all three groups of runners independent of running intensity. Conclusions The results suggest that suPAR can complement, but not replace CRP following ultra‐distance running in Tarahumara men and women.