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Predictors of interleukin‐1β and interleukin‐1 receptor antagonist in infant saliva
Author(s) -
Miller Elizabeth M.
Publication year - 2020
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.23477
Subject(s) - saliva , interleukin 1 receptor antagonist , medicine , population , anthropometry , immune system , interleukin , receptor antagonist , immunology , antagonist , receptor , environmental health , cytokine
Objectives This study assesses the feasibility of measuring interleukin‐1β (IL‐1β) and interleukin‐1 receptor antagonist (IL‐1ra) in infant salivary samples as representative of pro‐ and anti‐inflammatory processes, and explores predictors of these biomarkers in a US population. Methods Data were collected from 73 US mother‐infant pairs. Salivary samples were collected with an infant swab and analyzed for IL‐1β, IL‐1ra, and immunoglobulin A (IgA) using ELISA. Household, maternal, infant, and anthropometric predictors were selected using stepwise regression to build final multivariate models. Results Both IL‐1β and IL‐1ra can be feasibly measured in infant saliva. The predictors in the final IL‐1β model were IL‐1ra and reported infant illness. IL‐1β, IgA, infant age, household income, maternal BMI, and infant weight‐for‐age z ‐score were significant in the final model for IL‐1ra. Conclusions IL‐1β and IL‐ra are useful biomarkers of immune function for infants. In particular, IL‐1ra has the potential to address the relationship between immune function and body composition in the mother‐infant dyad.