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Relationship between fat distribution and cardiometabolic risk in Hispanic girls
Author(s) -
HetheringtonRauth Megan,
Bea Jennifer W.,
Lee Vinson R.,
Blew Robert M.,
Funk Janet L.,
Lohman Timothy G.,
Going Scott B.
Publication year - 2018
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.23149
Subject(s) - insulin resistance , medicine , endocrinology , homeostatic model assessment , body fat percentage , obesity , insulin
Objective In adults, certain body fat depots have greater impact on cardiometabolic risk than total adiposity. Whether similar relationships exist in children is uncertain. The aim of this study was to examine the relationships among dual x‐ray absorptiometry (DXA) measures of body fat distribution and total body adiposity with cardiometabolic risk factors in Hispanic girls. Methods Measures of total percent body fat, percent of total fat within the android, gynoid, leg, and trunk regions, and cardiometabolic biomarkers (insulin, glucose, homeostatic model assessment of insulin resistance (HOMA‐IR), triglycerides (TG), low and high lipoprotein cholesterol (LDL‐C, HDL‐C)) were obtained from 232 Hispanic girls (age 10.7 ±1.1 years). Regression models for each metabolic parameter were run against adiposity measures. Partial correlations of the adiposity measures were used to compare associations between adiposity measures and the cardiometabolic risk factors, controlling for somatic maturation. Results Total and regional adiposity were significantly related with cardiometabolic risk factors ( P < 0.05) except fasting glucose. The partial correlations of total and regional adiposity measures with each cardiometabolic biomarker were similar. More variance was explained for insulin and the HOMA‐IR (33%‐43%) than other risk factors. Partial correlations for the percentage of total fat in the gynoid and leg regions with insulin, HOMA‐IR, TG, and LDL‐C were negative, and positive with HDL‐C. Conclusion Measures of total and regional fat perform similarly in predicting cardiometabolic risk in Hispanic girls. A higher proportion of fat distributed in the gynoid or leg region is associated with lower cardiometabolic risk.