Relationship between adrenal steroid hormones in cord blood and birth weight: The Sapporo Cohort, Hokkaido Study on Environment and Children's Health | Zendy

Mitsui Takahiko | Zendy; Araki Atsuko | Zendy; Goudarzi Houman | Zendy; Miyashita Chihiro | Zendy; Ito Sachiko | Zendy; Sasaki Seiko | Zendy; Kitta Takeya | Zendy; Moriya Kimihiko | Zendy; Cho Kazutoshi | Zendy; Morioka Keita | Zendy; Kishi Reiko | Zendy; Shinohara Nobuo | Zendy; Takeda Masayuki | Zendy; omura Katsuya | Zendy

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Relationship between adrenal steroid hormones in cord blood and birth weight: The Sapporo Cohort, Hokkaido Study on Environment and Children's Health

Author(s) -

Mitsui Takahiko,

Araki Atsuko,

Goudarzi Houman,

Miyashita Chihiro,

Ito Sachiko,

Sasaki Seiko,

Kitta Takeya,

Moriya Kimihiko,

Cho Kazutoshi,

Morioka Keita,

Kishi Reiko,

Shinohara Nobuo,

Takeda Masayuki,

omura Katsuya

Publication year - 2018

Publication title -

american journal of human biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.559

H-Index - 81

eISSN - 1520-6300

pISSN - 1042-0533

DOI - 10.1002/ajhb.23127

Subject(s) - cortisone , dehydroepiandrosterone , androstenedione , medicine , birth weight , endocrinology , cord blood , hormone , low birth weight , cohort , physiology , prospective cohort study , pregnancy , androgen , biology , genetics

Objectives We investigated the relationship between steroid hormone levels in cord blood and birth weight. Methods Among 514 participants in a prospective birth cohort study in Sapporo, the following hormone levels were measured in 294 stored cord blood samples from 135 males and 159 females: androstenedione, dehydroepiandrosterone (DHEA), cortisol, and cortisone. Birth weight information was obtained from medical records. Results Androstenedione/DHEA was significantly higher in males than in females, while DHEA was significantly higher in females. Birth weight was significantly higher in males than in females. Regarding cortisone, androstenedione/DHEA, and cortisone/cortisol, a correlation was observed with birth weight in males but not in females. Conclusions Prenatal adrenal steroids as well as converting enzymes such as 11ß‐hydrosteroid dehydrogenase type 2 and 3ß‐hydrosteroid dehydrogenase may have an impact on prenatal physical development.

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