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Relationship between adrenal steroid hormones in cord blood and birth weight: The Sapporo Cohort, Hokkaido Study on Environment and Children's Health
Author(s) -
Mitsui Takahiko,
Araki Atsuko,
Goudarzi Houman,
Miyashita Chihiro,
Ito Sachiko,
Sasaki Seiko,
Kitta Takeya,
Moriya Kimihiko,
Cho Kazutoshi,
Morioka Keita,
Kishi Reiko,
Shinohara Nobuo,
Takeda Masayuki,
omura Katsuya
Publication year - 2018
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.23127
Subject(s) - cortisone , dehydroepiandrosterone , androstenedione , medicine , birth weight , endocrinology , cord blood , hormone , low birth weight , cohort , physiology , prospective cohort study , pregnancy , androgen , biology , genetics
Objectives We investigated the relationship between steroid hormone levels in cord blood and birth weight. Methods Among 514 participants in a prospective birth cohort study in Sapporo, the following hormone levels were measured in 294 stored cord blood samples from 135 males and 159 females: androstenedione, dehydroepiandrosterone (DHEA), cortisol, and cortisone. Birth weight information was obtained from medical records. Results Androstenedione/DHEA was significantly higher in males than in females, while DHEA was significantly higher in females. Birth weight was significantly higher in males than in females. Regarding cortisone, androstenedione/DHEA, and cortisone/cortisol, a correlation was observed with birth weight in males but not in females. Conclusions Prenatal adrenal steroids as well as converting enzymes such as 11ß‐hydrosteroid dehydrogenase type 2 and 3ß‐hydrosteroid dehydrogenase may have an impact on prenatal physical development.