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The interaction of cultural consonance and a polymorphism in the 2A serotonin receptor in relation to depression in Brazil: failure to replicate previous findings
Author(s) -
Dressler William W.,
Balieiro Mauro C.,
de Araújo Luiza Ferreira,
Silva Wilson A.,
dos Santos José ERNESTO
Publication year - 2016
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.22875
Subject(s) - hum , polymorphism (computer science) , replicate , depression (economics) , psychology , genotype , clinical psychology , genetics , gene , biology , history , statistics , mathematics , macroeconomics , performance art , economics , art history
Objectives To replicate a previously identified gene‐environment interaction between a genetic polymorphism in the serotonin 2A receptor and cultural consonance in family life in relation to depressive symptoms (Dressler et al., 2009). Methods A sample of 402 individuals in a sample drawn from four different economic strata in Ribeirão Preto, Brazil was interviewed and genotyped. Results Cultural consonance in family life has an inverse association with depressive symptoms (beta = −0.439, P < 0.001) and with high depressive symptoms (OR = 2.36, P < 0.001), but the interaction with genotype was not statistically significant. Conclusion The previously identified gene‐environment interaction was not replicated. Limitations of the study are discussed. Am. J. Hum. Biol. 28:936–940, 2016. © 2016Wiley Periodicals, Inc.
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