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GSTM1 , GSTP1 , and GSTT1 genetic variability in T urkish and worldwide populations
Author(s) -
Karaca Sefayet,
Karaca Mehmet,
Cesuroglu Tomris,
Erge Sema,
Polimanti Renato
Publication year - 2014
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.22671
Subject(s) - gstp1 , international hapmap project , genotyping , genetics , biology , genetic diversity , turkish population , genetic variation , genetic association , population , evolutionary biology , genotype , gene , medicine , single nucleotide polymorphism , environmental health
Objective Glutathione S‐transferase (GST) variants have been widely investigated to better understand their role in several pathologic conditions. To our knowledge, no data about these genetic polymorphisms within the Turkish population are currently available. The aim of this study was to analyze GSTM1 positive/null, GSTT1 positive/null, GSTP1*I105V (rs1695), and GSTP1*A114V (rs1138272) variants in the general Turkish population, to provide information about its genetic diversity, and predisposition to GST‐related diseases. Methods Genotyping was performed in 500 Turkish individuals using the Sequenom MassARRAY platform. A comparative analysis was executed using the data from the HapMap and Human Genome Diversity Projects (HGDP). Sequence variation was deeply explored using the Phase 1 data of the 1,000 Genomes Project. Results The variability of GSTM1 , GSTT1 , and GSTP1 polymorphisms in the Turkish population was similar to that observed in Central Asian, European, and Middle Eastern populations. The high linkage disequilibrium between GSTP1*I105V and GSTP1*A114V in these populations may have a confounding effect on GSTP1 genetic association studies. In analyzing GSTM1 , GSTT1 , and GSTP1 sequence variation, we observed other common functional variants that may be candidates for associated studies of diseases related to GST genes (e.g., cancer, cardiovascular disease, and allergy). Conclusions This study provides novel data about GSTM1 positive/null, GSTT1 positive/null, GSTP1*I105V, and GSTP1*A114V variants in the Turkish population, and other functional variants that may affect GSTM1 , GSTT1 , and GSTP1 functions among worldwide populations. This information can assist in the design of future genetic association studies investigating oxidative stress‐related diseases. Am. J. Hum. Biol. 27:310–316, 2015. © 2014 Wiley Periodicals, Inc.