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Molecular polymorphism of the ABO blood group: A study in Poland, Spain, and Andorra
Author(s) -
Umbria Miriam,
Cantons Jordi,
Bruguera Carmina,
Minias Alina,
Duró Chantal Backes,
Catalano Giulio,
Santos Cristina,
Nogués Ramon,
Aluja Maria Pilar
Publication year - 2014
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.22544
Subject(s) - abo blood group system , allele , peripheral blood , polymorphism (computer science) , exon , biology , genetics , gene , immunology
Objectives The main goal of this study is to increase knowledge on the molecular level of the ABO blood group system in Europe by providing data for Poland, Spain, and Andorra populations. Methods A total of 172 oral scrapings samples from individuals of Polish origin, 108 peripheral blood samples of autochthonous individuals from the province of Zamora (Spain), and 81 peripheral blood samples from individuals with Andorran origin, were analyzed. Molecular characterization of the allelic variants was performed by the analysis of exons 6 and 7 of the ABO gene. Results Seven common alleles were identified, namely: A101 , A102 , A201 , B101 , O01 , O02 , and O03 . Less common variants ( O05 , O09 , O21 , O26 , O06 , O11 , and O12 ), were also detected. Conclusions The results obtained contribute to the knowledge of the molecular European ABO map, and are discussed in regard to the allelic frequency reported by other Caucasian and Asian populations. Am. J. Hum. Biol. 26:556–558, 2014. © 2014 Wiley Periodicals, Inc.