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Correlation analysis of genetic admixture and social identification with body mass index in a Native American Community
Author(s) -
NordenKrichmar Trina M.,
Gizer Ian R.,
Libiger Ondrej,
Wilhelmsen Kirk C.,
Ehlers Cindy L.,
Schork Nicholas J.
Publication year - 2014
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.22521
Subject(s) - body mass index , socioeconomic status , demography , obesity , hum , population , ethnic group , ancestry informative marker , gerontology , scale (ratio) , medicine , psychology , geography , biology , genetics , sociology , genotype , anthropology , allele frequency , cartography , art , performance art , art history , gene
Objectives Body mass index (BMI) is a well‐known measure of obesity with a multitude of genetic and non‐genetic determinants. Identifying the underlying factors associated with BMI is difficult because of its multifactorial etiology that varies as a function of geoethnic background and socioeconomic setting. Thus, we pursued a study exploring the influence of the degree of Native American admixture on BMI (as well as weight and height individually) in a community sample of Native Americans ( n = 846) while accommodating a variety of socioeconomic and cultural factors. Methods Participants' degree of Native American (NA) ancestry was estimated using a genome‐wide panel of markers. The participants also completed an extensive survey of cultural and social identity measures: the Indian Culture Scale (ICS) and the Orthogonal Cultural Identification Scale (OCIS). Multiple linear regression was used to examine the relation between these measures and BMI. Results Our results suggest that BMI is correlated positively with the proportion of NA ancestry. Age was also significantly associated with BMI, while gender and socioeconomic measures (education and income) were not. For the two cultural identity measures, the ICS showed a positive correlation with BMI, while OCIS was not associated with BMI. Conclusions Taken together, these results suggest that genetic and cultural environmental factors, rather than socioeconomic factors, account for a substantial proportion of variation in BMI in this population. Further, significant correlations between degree of NA ancestry and BMI suggest that admixture mapping may be appropriate to identify loci associated with BMI in this population. Am. J. Hum. Biol. 26:347–360, 2014. © 2014 Wiley Periodicals, Inc.