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Pathogenic and obesogenic factors associated with inflammation in Chinese children, adolescents and adults
Author(s) -
Thompson Amanda L.,
Houck Kelly M.,
Adair Linda,
GordonLarsen Penny,
Du Shufa,
Zhang Bing,
Popkin Barry
Publication year - 2013
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.22462
Subject(s) - overweight , medicine , waist , obesity , relative risk , disease , confidence interval , immunology
Objectives Influenced by pathogen exposure and obesity, inflammation provides a critical biological pathway linking changing environments to the development of cardiometabolic disease. This study tests the relative contribution of obesogenic and pathogenic factors to moderate and acute CRP elevations in Chinese children, adolescents and adults. Methods Data come from 8795 participants in the China Health and Nutrition Study. Age‐stratified multinomial logistic models were used to test the association between illness history, pathogenic exposures, adiposity, health behaviors and moderate (1–10 mg/L in children and 3–10 mg/L in adults) and acute (>10mg/L) CRP elevations, controlling for age, sex and clustering by household. Backward model selection was used to assess which pathogenic and obesogenic predictors remained independently associated with moderate and acute CRP levels when accounting for simultaneous exposures. Results Overweight was the only significant independent risk factor for moderate inflammation in children (RRR 2.10, 95%CI 1.13‐3.89). History of infectious (RRR 1.28, 95%CI 1.08‐1.52) and non‐communicable (RRR 1.37, 95%CI 1.12‐1.69) disease, overweight (RRR 1.66, 95%CI 1.45‐1.89) and high waist circumference (RRR 1.63, 95%CI 1.42‐1.87) were independently associated with a greater likelihood of moderate inflammation in adults while history of infectious disease (RRR 1.87, 95%CI 1.35‐2.56) and overweight (RRR 1.40, 95%CI 1.04‐1.88) were independently associated with acute inflammation. Environmental pathogenicity was associated with a reduced likelihood of moderate inflammation, but a greater likelihood of acute inflammation in adults. Conclusions These results highlight the importance of both obesogenic and pathogenic factors in shaping inflammation risk in societies undergoing nutritional and epidemiological transitions. Am. J. Hum. Biol. 26:18–28, 2014. © 2013 Wiley Periodicals, Inc.