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Expression pattern of the transforming growth factor β signaling genes in human peripheral blood mononuclear cells after exercise—inflammatory aspects
Author(s) -
Kimsa Magdalena,
StrzalkaMrozik Barbara,
Kimsa Malgorzata,
Gola Joanna,
KochanskaDziurowicz Aleksandra,
Zebrowska Aleksandra,
Janikowska Grazyna,
Mazurek Urszula,
Jonczyk Szymon
Publication year - 2012
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.22311
Subject(s) - peripheral blood mononuclear cell , signal transduction , transforming growth factor , microarray , gene , gene expression , immune system , biology , peripheral blood , immunology , inflammation , medicine , microbiology and biotechnology , genetics , in vitro
Objective: The present study has focused on the identification of differences between the expression pattern of TGF‐β signaling pathway genes in athletes after exercise. Materials and methods: The study group consisted of three healthy cyclists, which were collected pre‐exercise, immediately postexercise, and after 15 min of recovery. The analysis of the expression profile of genes related to the TGF‐β signal transduction pathway was performed in peripheral blood mononuclear cells using HG‐U133A oligonucleotide microarrays. Results: A significant differential gene expression was recorded for RUNX3, TGFBR3, MLC1, and GRB2. Conclusions: The effect of physical exercise on immune response may be essential for human health. Moreover, alterations of TGF‐β signaling can be involved in the process of adaptation of human organism to physical exertion. Am. J. Hum. Biol., 2012. © 2012 Wiley Periodicals, Inc.