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Associations of long‐chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates
Author(s) -
Kilari Anitha,
Mehendale Savita,
Dangat Kamini,
Pisal Hemlata,
Joshi Sadhana
Publication year - 2010
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.21129
Subject(s) - docosahexaenoic acid , polyunsaturated fatty acid , birth weight , low birth weight , arachidonic acid , cord blood , medicine , hum , fatty acid , pregnancy , obstetrics , physiology , biology , biochemistry , art , genetics , performance art , art history , enzyme
The purpose of this study was to examine the maternal and cord long‐chain polyunsaturated fatty acid (LCPUFA) concentrations and their associations with birth outcome in term deliveries. Pregnant women ( n = 253) delivering at term were divided into two groups based on their babies' birth weights (1) normal birth weight (NBW), that is, ≥2.5 kg ( n = 190) and (2) low‐birth weight (LBW), that is, <2.5 kg ( n = 63). Each group is further divided into two groups according to the baby's sex, that is, male NBW (M‐NBW), female NBW (F‐NBW), male LBW (M‐LBW), and female LBW (F‐LBW) groups. Maternal plasma docosahexaenoic acid and erythrocyte arachidonic acid (AA) levels were lower ( P < 0.05 for both), while cord plasma docosahexaenoic acid and erythrocyte AA levels were higher ( P < 0.05 for both) in LBW group when compared to the NBW group. Maternal erythrocyte AA levels were positively associated with birth weight ( P = 0.001), while cord plasma docosahexaenoic acid levels were negatively ( P = 0.05) associated with birth weight. Reduced maternal and increased cord LCPUFA levels exist in mothers delivering LBW babies, especially in mothers delivering female babies, indicative of sex‐specific effects. Am. J. Hum. Biol., 2011. © 2010 Wiley‐Liss, Inc.