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Adiponectin and type 2 diabetes in Samoan adults
Author(s) -
Dibello Julia R.,
Baylin Ana,
Viali Satupaitea,
Tuitele John,
Bausserman Linda,
Mcgarvey Stephen T.
Publication year - 2008
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.20858
Subject(s) - samoan , adiponectin , prediabetes , pacific islanders , type 2 diabetes , medicine , odds ratio , diabetes mellitus , obesity , body mass index , endocrinology , insulin resistance , environmental health , population , philosophy , linguistics
Objective: Previous studies have established an association between adiponectin and type 2 diabetes. It is unclear whether adiponectin will be useful among Samoan Islanders, characterized by markedly elevated levels of obesity, in differentiating those at risk of developing type 2 diabetes. Methods: Cross‐sectional, genetic epidemiology study of obesity in American Samoa and Samoa 2002–2003 ( n = 1,599). Logistic regression provided adjusted odds ratios and 95% confidence intervals for the association between adiponectin, diabetes, and prediabetes (impaired fasting glucose). Results: There is a significant decreasing trend in the odds of diabetes and prediabetes across increasing quintiles of adiponectin with an OR of 2.8 (95% CI: 1.6, 5.0) and 2.9 (95% CI: 1.5, 5.7), respectively, in the lowest relative to the highest quintile of adiponectin ( P ‐for‐trend = 0.004 and 0.001). Conclusions: Adiponectin is an important correlate, independent of other risk factors, of the pathogenesis of type 2 diabetes among Samoan islanders and may help distinguish those at higher risk of developing this disease. Am. J. Hum. Biol. 2009. © 2008 Wiley‐Liss, Inc.