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Recurrent mutation in SNPs within Y chromosome E3b (E‐M215) haplogroup: A rebuttal
Author(s) -
Cruciani Fulvio,
Trombetta Beniamino,
Novelletto Andrea,
Scozzari Rosaria
Publication year - 2008
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.20790
Subject(s) - rebuttal , haplogroup , genetics , single nucleotide polymorphism , mutation , biology , y chromosome , evolutionary biology , haplotype , allele , gene , genotype , geography , archaeology
In a previous issue of AJHB, Fernandes et al. (2008. Am J Hum Biol 20:185–190.) describe instances of identity by state at multiple short tandem repeat loci between human Y chromosomes belonging to different E‐M35 sub‐haplogroups. They interpret these findings as evidence for multiple mutational events in at least two loci (M78 and M81). Here, we introduce a novel polymorphic marker (V68), potentially useful to investigate the issue. This marker and sequence data, reported here for the first time, reinforce our previous interpretations on the phylogenetic structure of the E3b haplogroup. We discuss these results in the frame of general approaches to attain robust phylogenetic inferences based on biallelic polymorphism data. Am. J. Hum. Biol., 2008. © 2008 Wiley‐Liss, Inc.