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β‐Globin gene cluster haplotypes and α‐thalassemia in sickle cell disease patients from Trinidad
Author(s) -
JonesLecointe Altheia,
Smith Erskine,
Romana Marc,
Gilbert MarieGeorges,
Charles Waveney P.,
SaintMartin Christian,
Kéclard Lisiane
Publication year - 2008
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.20732
Subject(s) - haplotype , hemoglobinopathy , thalassemia , sickle cell anemia , disease , globin , biology , gene , genetics , geography , genotype , medicine , cell
In this study, we have determined the frequency of β S haplotypes in 163 sickle cell disease patients from Trinidad. The α 3.7 globin gene deletion status was also studied with an observed gene frequency of 0.17. Among the 283 β S chromosomes analyzed, the Benin haplotype was the most prevalent (61.8%) followed by Bantu (17.3%), Senegal (8.5%), Cameroon (3.5%), and Arab‐Indian (3.2%), while 5.7% of them were atypical. This β S haplotypes distribution differed from those previously described in other Caribbean islands (Jamaica, Guadeloupe, and Cuba), in agreement with the known involvement of the major colonial powers (Spain, France, and Great Britain) in the slave trade in Trinidad and documented an Indian origin of the β S gene. Am. J. Hum. Biol., 2008. © 2008 Wiley‐Liss, Inc.