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Genetic structure of Mexican Mestizo women with breast cancer based on three STR loci
Author(s) -
CalderónGarcidueñas Ana L.,
RiveraPrieto Roxana A.,
OrtízLopez Rocio,
Rivas Fernando,
BarreraSaldaña Hugo A.,
PeñalozaEspinosa Rosenda I.,
CerdaFlores Ricardo M.
Publication year - 2008
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.20713
Subject(s) - hum , grandparent , genotype , population , demography , breast cancer , allele , genetics , allele frequency , biology , cancer , gene , history , psychology , developmental psychology , sociology , performance art , art history
The aim of this population genetics study was to compare the genetic structure of Mexican women with breast cancer (BrCa) with previously reported data of four random populations (Nuevo León, Hispanics, Chihuahua, and Central Region of Mexico). A sample of 115 unrelated women with BrCa and whose four grandparents were born in five zones of Mexico were interviewed at a reference hospital in Northeastern Mexico. Noncodifying STRs D7S820, D13S317, and D16S39 were analyzed; genotype distribution was in agreement with Hardy–Weinberg expectations for all three markers. Similar allele frequencies among four random populations and this selected population were found. According with this and previous studies using molecular and nonmolecular nuclear DNA markers not associated with any disease, Mexican Mestizo population is genetically homogeneous and therefore, genetic causes of BrCa are less heterogeneous, simplifying genetic epidemiologic studies. Am. J. Hum. Biol., 2008. © 2008 Wiley‐Liss, Inc.