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Common set of genes regulates low‐density lipoprotein size and obesity‐related factors in Alaskan Eskimos: Results from the GOCADAN Study
Author(s) -
Voruganti V. Saroja,
Cai Guowen,
Cole Shelley A.,
FreelandGraves Jeanne H.,
Laston Sandra,
Wenger Charlotte R.,
MacCluer Jean W.,
Dyke Bennett,
Devereux Richard,
Ebbesson Sven O.E.,
Fabsitz Richard R.,
Howard Barbara V.,
Comuzzie Anthony G.
Publication year - 2006
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.20527
Subject(s) - waist , obesity , body mass index , medicine , triglyceride , lipoprotein , endocrinology , cholesterol
Increasing incidence of cardiovascular disease in traditionally low‐risk Alaskan Eskimos is a cause for concern. The purpose of this study was to examine the genetic and environmental correlations of low‐density lipoprotein (LDL) subfractions with obesity‐related factors in Alaskan Eskimos, using data from the first 954 participants of the Genetics of Coronary Artery Disease in Alaska Natives Study. Estimates of genetic and environmental influence were calculated using a maximum likelihood variance component method implemented in SOLAR. Mean values of weight, body mass index (BMI), and waist were 73.4 ± 0.5 kg, 27.6 ± 0.2 kg/m 2 , and 88.0 ± 0.4 cm, respectively. LDL, and its small (LDL1), medium (LDL2), and large (LDL3) subfractions, had mean values of 115.8 ± 1.2 mg/dl, 8.3 ± 0.4 mg/dl, 19.6 ± 0.8 mg/dl, and 71.5 ± 1.5 mg/dl, respectively. Bivariate analysis displayed significant genetic correlations between LDL subfractions and obesity‐related factors: LDL1 with BMI (rho G = 0.67, P < 0.05), waist (rho G = 0.80, P < 0.001), and subscapular and tricep skinfolds (rho G = 0.93, P < 0.005, and rho G = 0.78, P < 0.05, respectively); LDL2 with BMI (rho G = 0.52, P < 0.05), waist (rho G = 0.46, P < 0.05), and tricep skinfold (rho G = 0.60, P < 0.05); and mean LDL size with BMI (rho G = −0.36), waist (rho G = −0.42,), and subscapular and tricep skinfolds (rho G = −0.44 and −0.43, respectively) ( P < 0.005). These results show that a common set of genes is influencing LDL size and obesity‐related factors in Alaskan Eskimos. Am. J. Hum. Biol. 18:525–531, 2006. © 2006 Wiley‐Liss, Inc.