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Genetic studies of human apolipoproteins: XII. Population genetics of apolipoproteins in Papua New Guinea
Author(s) -
Kamboh M. I.,
Bhatia Kuldeep K.,
Ferrell R. E.
Publication year - 1990
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.1310020103
Subject(s) - new guinea , genetics , population genetics , genetic data , biology , population , evolutionary biology , medicine , ethnology , history , environmental health
The gene products of the apolipoprotein A‐I, A‐II, A‐IV, C‐II, C‐III, D, E and H loci have been screened by isoelectric focusing followed by immunoblotting from two Papua New Guinean populations, the Huli and the Pawaia. Only APO E and APO H revealed common polymorphisms. A putative unique A‐IV variant has been identified, but due to the lack of family data it is not characterized further. Three common APO H alleles were observed in both groups with comparable frequencies. But significantly different distributions of three APO E alleles were noted in the Huli and the Pawaia. The respective frequencies of the APO E *2, APO E *3, and APO E *4 alleles were 0.154, 0.356, and 0.490 in the Huli and 0.138, 0.603, and 0.259 in the Pawaia. A strikingly high frequency of the APO E *4 allele in Papua New Guinea may provide a useful insight into the studies of genetic and environmental interactions in controlling the cholesterol levels in the general population.