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Genetic structure of seven Mexican indigenous populations based on five polymarker loci
Author(s) -
BuentelloMalo Leonora,
PeñalozaEspinosa Rosenda I.,
Loeza Francisco,
SalamancaGomez Fabio,
CerdaFlores Ricardo M.
Publication year - 2003
Publication title -
american journal of human biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 81
eISSN - 1520-6300
pISSN - 1042-0533
DOI - 10.1002/ajhb.10116
Subject(s) - indigenous , genetic diversity , biology , population , genetic variation , genetics , human genetic variation , genetic structure , evolutionary biology , geography , gene , demography , ecology , genome , sociology , human genome
This descriptive study investigates the genetic structure of seven Mexican indigenous populations (Mixteca Alta, Mixteca Baja, Otomies, Purepecha, Nahuas‐Guerrero, Nahuas‐Xochimilco, and Tzeltales) on the basis of five PCR‐based polymorphic DNA loci: LDLR, GYPA, HBGG, D7S8, and GC. Genetic distance and diversity analyses indicate that these Mexican indigenous are similar and that more than 96% of the total gene diversity (H T ) can be attributed to individual variation within populations. Mixteca‐Alta, Mixteca‐Baja, and Nahuas‐Xochimilco show indications of higher admixture with European‐derived persons. The demonstration of a relative genetic homogeneity of Mexican Indians for the markers studied suggests that this population is suitable for studying disease‐marker associations in the search for candidate genes of complex diseases. Am. J. Hum. Biol. 15:23–28, 2003. © 2002 Wiley‐Liss, Inc.