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Lymphocytosis of large granular lymphocytes in patients with hodgkin's disease
Author(s) -
Kingreen Dorothea,
Dalal Bakul I.,
Heyman Meyer,
Phillips Gordon L.,
Horsman Doug,
Kidd Pamela,
Loughran Thomas P.
Publication year - 1995
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830500403
Subject(s) - lymphocytosis , immunophenotyping , lymphoma , cd3 , medicine , leukemia , pathology , immunology , disease , flow cytometry , cd8 , antigen
Clonal disorders of large granular lymphocytes (LGL) of either CD3‐ (NK cell) or CD 3+ (T‐cell) phenotype have been described. B‐cell malignancies such as hairy cell leukemia and non‐Hodgkin's lymphoma have been observed in association with the T‐cell type of LGL leukemia. Here we report the occurrence of LGL lymphocytosis in four patients with Hodgkin's disease. Immunophenotyping studies showed that these LGL were CD 3‐ in three patients and CD3+ in the other. LGL were polyclonally expanded in both patients in whom clonality could be assessed.