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Steroid‐responsive pulmonary disorders associated with myelodysplastic syndromes with der(1q;7p) chromosomal abnormality
Author(s) -
Matsushima Takafumi,
Murakami Hirokazu,
Kim Koho,
Uchiumi Hideki,
Murata Naoya,
Tamura Jun'Ichi,
Sawamura Morio,
Karasawa Masamitsu,
Naruse Takuji,
Tsuchiya Jun
Publication year - 1995
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830500207
Subject(s) - hypergammaglobulinemia , medicine , eosinophilia , pleural effusion , pulmonary eosinophilia , pathology , abnormality , pneumonia , bone marrow , gastroenterology , immunology , bronchoalveolar lavage , lung , disease , psychiatry
We report three patients with pulmonary disorders associated with myelodysplastic syndromes (MDS). All three patients had symptoms of pyrexia and respiratory discomfort. One patient had pulmonary eosinophilia with bilateral pleural effusion, one had interstitial pneumonia, and one had bilateral pleural effusion caused by systemic vasculitis. Elevated C‐reactive protein (CRP) levels, polyclonal hypergammaglobulinemia, and morphological abnormalities in peripheral blood were observed in all three patients. The bone marrow of these patients revealed trilineage dysplasia and eosinophilia. Cytogenetic analysis showed [46,XY,‐7,+der(1q;7p)]. Antibiotic treatment was not effective. However, improvement was dramatic after corticosteroid treatment; CRP levels were reduced and the hypergammaglobulinemia was improved. These cases suggest that MDS with [‐7,+der(1q;7p)] may be correlated with bone marrow eosinophilia and that an immunologic abnormality may be involved in the pulmonary disorders.