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Serum concentrations of IL‐5, GM‐CSF, and IL‐3 and the production by lymphocytes in various eosinophilia
Author(s) -
Koike Toshiyuki,
Enokihara Hideo,
Arimura Hironari,
Ninomiya Haruhiko,
Yamashiro Kyoko,
Tsuruoka Nobuo,
Tsujimoto Masafumi,
Aoyagi Masakuni,
Watanabe Kanji,
Nakamura Yuuichi,
Saitou Kenji,
Furusawa Shimpei,
Shishido Hideo
Publication year - 1995
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830500205
Subject(s) - eosinophilia , granulocyte macrophage colony stimulating factor , interleukin 5 , interleukin 2 , interleukin , immunology , interleukin 3 , lymphocyte , medicine , cytokine , endocrinology , chemistry , t cell , immune system , il 2 receptor
The concentrations of interleukin‐5 (IL‐5), granulocyte‐macrophage colony‐stimulating factor GM‐CSF, and interleukin‐3 (IL‐3) in serum and in IL‐2‐stimulated lymphocyte culture medium (L‐IL2‐CM) prepared from patients with reactive eosinophilia were measured by enzyme‐linked immunosorbent assay (ELISA). Serum IL‐5 levels were increased in 16 out of 42 cases. GM‐CSF and IL‐3 were below the detectable levels in all sera examined. The concentrations of IL‐5 and GM‐CSF in L‐IL2‐CM were increased in 10 out of 29 patients. IL‐3 was below the detectable levels in all L‐IL2‐CM.