Simultaneous occurrence of tetrasomy 21 and trisomy 8 in a patient with early blastic metamorphosis of chronic myeloproliferative disorder | Zendy

Sebastio Lucia | Zendy; Ferrara Felicetto | Zendy; Vicari Laura | Zendy; Noto Rosella Di | Zendy; Vecchio Luigi Del | Zendy; Pane Fabrizio | Zendy; Fasanaro Alfredo | Zendy; Cimino Renato | Zendy; Salvatore Francesco | Zendy; Ventruto Valerio | Zendy

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Simultaneous occurrence of tetrasomy 21 and trisomy 8 in a patient with early blastic metamorphosis of chronic myeloproliferative disorder

Author(s) -

Sebastio Lucia,

Ferrara Felicetto,

Vicari Laura,

Noto Rosella Di,

Vecchio Luigi Del,

Pane Fabrizio,

Fasanaro Alfredo,

Cimino Renato,

Salvatore Francesco,

Ventruto Valerio

Publication year - 1995

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830500110

Subject(s) - tetrasomy , karyotype , trisomy , biology , cancer research , retinoic acid , genetics , immunology , chromosome , medicine , pathology , cell culture , gene

We report an unusual hyperdiploid karyotype characterized by the simultaneous occurrence of tetrasomy 21 and trisomy 8 detected during early blastic evolution of a BCR‐ABL‐negative chronic myeloproliferative disorder. Blast cells from this patient showed a striking response to all‐trans‐retinoic acid (ATRA)‐induced differentiation as evaluated by CD15 expression following in vitro exposure to this inducer. Our report represents the first description of such a composite karyotype in human hematologic malignancies.

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