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Simultaneous occurrence of tetrasomy 21 and trisomy 8 in a patient with early blastic metamorphosis of chronic myeloproliferative disorder
Author(s) -
Sebastio Lucia,
Ferrara Felicetto,
Vicari Laura,
Noto Rosella Di,
Vecchio Luigi Del,
Pane Fabrizio,
Fasanaro Alfredo,
Cimino Renato,
Salvatore Francesco,
Ventruto Valerio
Publication year - 1995
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830500110
Subject(s) - tetrasomy , karyotype , trisomy , biology , cancer research , retinoic acid , genetics , immunology , chromosome , medicine , pathology , cell culture , gene
We report an unusual hyperdiploid karyotype characterized by the simultaneous occurrence of tetrasomy 21 and trisomy 8 detected during early blastic evolution of a BCR‐ABL‐negative chronic myeloproliferative disorder. Blast cells from this patient showed a striking response to all‐trans‐retinoic acid (ATRA)‐induced differentiation as evaluated by CD15 expression following in vitro exposure to this inducer. Our report represents the first description of such a composite karyotype in human hematologic malignancies.