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Sickle cell anemia, right atrial thrombosis, and the antiphospholipid antibody
Author(s) -
Yeghen T.,
Benjamin S.,
Boyd O.,
Pumphrey C.,
Bevan D. H.
Publication year - 1995
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830500109
Subject(s) - medicine , thrombosis , antibody , sickle cell anemia , cardiology , anemia , hemolytic anemia , immunology , disease
We report a patient with sickle cell anemia (homozygous Hb SS) and typical features of sickle chest syndrome but with no response to exchange transfusion. A right atrial thrombus was found, and antiphospholipid antibodies were detected in his blood. He responded to thrombolytic therapy. The relationship between right atrial thrombus and massive pulmonary embolus, and the implications of an additional thrombophilic state in sickle cell disease are discussed.