Cytokine profile in acute myelofibrosis associated with aggressive large granular lymphocyte leukemia | Zendy

Dalal Bakul I. | Zendy; Keown Paul A. | Zendy; Paraskevas Frixos | Zendy; Williams Gaynor | Zendy; Johnston James B. | Zendy

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Cytokine profile in acute myelofibrosis associated with aggressive large granular lymphocyte leukemia

Author(s) -

Dalal Bakul I.,

Keown Paul A.,

Paraskevas Frixos,

Williams Gaynor,

Johnston James B.

Publication year - 1995

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830490415

Subject(s) - myelofibrosis , cytokine , cd5 , immunology , medicine , leukemia , lymphocyte , acute leukemia , bone marrow , flow cytometry

We report a patient with acute large granular lymphocyte (LGL) leukemia, presenting as acute myelofibrosis (AMF). The leukemic cells were immature T‐cells (CD5+, CD7+, CD16−, CD56−, CD57−, and CD41−), had monosomy 7, and secreted large amounts of Transforming Growth Factor‐β1(TGF‐β1). The serum levels of interleukins (IL)‐2, ‐2R, ‐6 and ‐8 were elevated, while the IL‐1<β, IL‐4, and tumor necrosis factor‐α were normal. © 1995 Wiley‐Liss, Inc.

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