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Cytokine profile in acute myelofibrosis associated with aggressive large granular lymphocyte leukemia
Author(s) -
Dalal Bakul I.,
Keown Paul A.,
Paraskevas Frixos,
Williams Gaynor,
Johnston James B.
Publication year - 1995
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830490415
Subject(s) - myelofibrosis , cytokine , cd5 , immunology , medicine , leukemia , lymphocyte , acute leukemia , bone marrow , flow cytometry
We report a patient with acute large granular lymphocyte (LGL) leukemia, presenting as acute myelofibrosis (AMF). The leukemic cells were immature T‐cells (CD5+, CD7+, CD16−, CD56−, CD57−, and CD41−), had monosomy 7, and secreted large amounts of Transforming Growth Factor‐β1(TGF‐β1). The serum levels of interleukins (IL)‐2, ‐2R, ‐6 and ‐8 were elevated, while the IL‐1<β, IL‐4, and tumor necrosis factor‐α were normal. © 1995 Wiley‐Liss, Inc.