Factor V Leiden (FVQ 506) is common in a Brazilian population | Zendy

Arruda Valder R. | Zendy; AnnichinoBizzacchi Joyce M. | Zendy; Costa Fernando F. | Zendy; Reitsma Pieter H. | Zendy

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Factor V Leiden (FVQ 506) is common in a Brazilian population

Author(s) -

Arruda Valder R.,

AnnichinoBizzacchi Joyce M.,

Costa Fernando F.,

Reitsma Pieter H.

Publication year - 1995

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830490312

Subject(s) - factor v leiden , missense mutation , medicine , venous thrombosis , risk factor , factor v , thrombosis , protein c , population , thrombophilia , activated protein c resistance , allele frequency , gastroenterology , mutation , immunology , genetics , allele , gene , biology , environmental health

Resistance to activated protein C (APC) is the most common risk factor in venous thrombosis. A missense mutation in the factor V gene (factor V Leiden) is the molecular basis for this phenotype. Factor V Leiden was previously found in about 20% of unselected patients with thrombosis but also occurred in 3‐5% of healthy Dutch controls. In the present study of Brazilian patients with venous thrombosis we also observed a frequency of 20% for this factor. In addition, in healthy Brazilian controls the frequency of the mutation was 2%. These data suggest that factor V Leiden has a similar distribution worldwide irrespective of the ethnic origin of the population. © 1995 Wiley‐Liss, Inc.

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