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Factor V Leiden (FVQ 506) is common in a Brazilian population
Author(s) -
Arruda Valder R.,
AnnichinoBizzacchi Joyce M.,
Costa Fernando F.,
Reitsma Pieter H.
Publication year - 1995
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830490312
Subject(s) - factor v leiden , missense mutation , medicine , venous thrombosis , risk factor , factor v , thrombosis , protein c , population , thrombophilia , activated protein c resistance , allele frequency , gastroenterology , mutation , immunology , genetics , allele , gene , biology , environmental health
Abstract Resistance to activated protein C (APC) is the most common risk factor in venous thrombosis. A missense mutation in the factor V gene (factor V Leiden) is the molecular basis for this phenotype. Factor V Leiden was previously found in about 20% of unselected patients with thrombosis but also occurred in 3‐5% of healthy Dutch controls. In the present study of Brazilian patients with venous thrombosis we also observed a frequency of 20% for this factor. In addition, in healthy Brazilian controls the frequency of the mutation was 2%. These data suggest that factor V Leiden has a similar distribution worldwide irrespective of the ethnic origin of the population. © 1995 Wiley‐Liss, Inc.