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Higher cytotoxic activity and increased levels of IL‐1β, IL‐6, and TNF‐α in patients undergoing cardiopulmonary bypass
Author(s) -
Martí Francesc,
Muñoz Joan,
Peiró Matilde,
Bertran Esther,
Ferrán Carme,
Octavio Carmen,
García Juan,
Rueda FÈLix
Publication year - 1995
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830490310
Subject(s) - cardiopulmonary bypass , medicine , cytotoxic t cell , tumor necrosis factor alpha , interleukin 6 , cytokine , immunology , biology , biochemistry , in vitro
Extracorporeal circulation (EC) by surgical bypass is often associated with a systemic inflammatory response. The purpose of this study was to assess the effect of EC on the serum levels of pro‐inflammatory mediators Interleukin (IL)‐1β, IL‐6, tumor necrosis factor (TNF)‐α, and soluble CD‐23. Peripheral blood lymphocyte subsets and natural killer cell (NK) cytotoxic activity were also analyzed before and after the bypass process. The results from eight patients who underwent cardiac surgery showed a significant increase in the levels of IL‐1β, IL‐6, and TNF‐α, a decrease in CD4 + /CD8 + lymphocyte ratio, and an overstimulated NK cytotoxic activity. These changes on serum cytokine levels and cellular immunology parameters could play an important role in the development of adverse effects associated with EC. © 1995 Wiley‐Liss, Inc.