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T‐Cell large granular lymphocytic leukemia following orthotopic liver transplantation
Author(s) -
Feher O.,
Barilla D.,
Locker J.,
Oliveri D.,
Melhem M.,
Winkelstein A.
Publication year - 1995
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830490307
Subject(s) - lymphoproliferative disorders , transplantation , chronic lymphocytic leukemia , leukemia , gene rearrangement , pathology , immunology , medicine , genotype , bone marrow , lymphoma , cancer research , biology , gene , genetics
Aggressive T‐cell neoplasms are an infrequent complication of allogeneic organ and bone marrow transplantation. To date, chronic T‐cell lymphoproliferative malignancies have not been described. The present case documents the occurrence of a T‐cell large granular lymphocytic leukemia (T‐LGL) in a patient following orthotopic liver transplantation. Genotype studies showed a clonal T‐cell receptor α‐chain gene rearrangement. A unique feature was the detection of a specific chromosomal deletion at 1p32 involving the tal‐1 gene, an abnormality previously described only in aggressive T‐cell neoplasms. © 1995 Wiley‐Liss, Inc.