Inhibitory activity of anti‐β 2 ‐glycoprotein I antibody on factor va degradation by activated‐protein C and its cofactor protein S | Zendy

Matsuda Juzo | Zendy; Gohchi Kengo | Zendy; Kawasugi Kazuo | Zendy; Gotoh Moritaka | Zendy; Saitoh Noriko | Zendy; Tsukamoto Miyo | Zendy

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Inhibitory activity of anti‐β 2 ‐glycoprotein I antibody on factor va degradation by activated‐protein C and its cofactor protein S

Author(s) -

Matsuda Juzo,

Gohchi Kengo,

Kawasugi Kazuo,

Gotoh Moritaka,

Saitoh Noriko,

Tsukamoto Miyo

Publication year - 1995

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830490116

Subject(s) - glycoprotein , antibody , microbiology and biotechnology , protein c , pathogenesis , chemistry , biology , biochemistry , immunology

We investigated the influence of anti‐β 2 ‐glycoprotein I (aGPI), which recently has come to be regarded as anti‐cardiolipin antibody (aCL) itself, on factor Va (FVa) degradation by activated protein C/protein S system. We found that aGPI had an inhibitory effect on FVa degradation with β 2 ‐glycoprotein I‐dependency, thus suggesting aGPI/aCL is a highly possible factor as the pathogenesis of thrombosis observed in aGPI/aCL‐positive patients. © 1995 Wiley‐Liss, Inc.

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