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Inhibitory activity of anti‐β 2 ‐glycoprotein I antibody on factor va degradation by activated‐protein C and its cofactor protein S
Author(s) -
Matsuda Juzo,
Gohchi Kengo,
Kawasugi Kazuo,
Gotoh Moritaka,
Saitoh Noriko,
Tsukamoto Miyo
Publication year - 1995
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830490116
Subject(s) - glycoprotein , antibody , microbiology and biotechnology , protein c , pathogenesis , chemistry , biology , biochemistry , immunology
We investigated the influence of anti‐β 2 ‐glycoprotein I (aGPI), which recently has come to be regarded as anti‐cardiolipin antibody (aCL) itself, on factor Va (FVa) degradation by activated protein C/protein S system. We found that aGPI had an inhibitory effect on FVa degradation with β 2 ‐glycoprotein I‐dependency, thus suggesting aGPI/aCL is a highly possible factor as the pathogenesis of thrombosis observed in aGPI/aCL‐positive patients. © 1995 Wiley‐Liss, Inc.