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Molecular cytogenetic analysis of monosomy 7 in pediatric patients with myelodysplastic syndrome
Author(s) -
Harrison K.J.,
Massing B.,
McKenna C.,
Kalousek D.K.
Publication year - 1995
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830480204
Subject(s) - monosomy , interphase , biology , chromosome 7 (human) , aneuploidy , population , cytogenetics , myelodysplastic syndromes , chromosome , genetics , karyotype , pathology , bone marrow , immunology , medicine , gene , environmental health
Abstract Monosomy 7 is a non‐random cytogenetic abnormality that is frequently associated with myelodysplastic syndromes (MDS). Twenty‐four bone marrow samples from five pediatric patients with MDS were analysed using both traditional and Interphase cytogenetic analysis. The majority of the metaphases were monosomic for chromosome 7 while interphase cytogenetic analysis consistently detected a disomic cell population in nondividing cell populations. This suggests that the monosomy 7 cells have a distinct proliferative advantage compared to the disomic cell population. The results demonstrate that interphase cytogenetic analysis provides important cytogenetic information about non‐dividing cell subpopulations, enhancing our understanding of the cell dynamics of normal and monosomy 7 cells in MDS.