Premium
Acute megakaryoblastic leukemia following transient myeloproliferative disorder in a patient without down syndrome
Author(s) -
Brissette Mark D.,
DuvalArnould Bertrand J.,
Gordon Bruce G.,
Cotelingam James D.
Publication year - 1994
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830470413
Subject(s) - acute megakaryoblastic leukemia , down syndrome , immunophenotyping , trisomy , medicine , myeloproliferative disorders , myeloid leukemia , bone marrow , karyotype , leukemia , haematopoiesis , pathology , aneuploidy , acute leukemia , myeloid , immunology , chromosome , genetics , biology , stem cell , flow cytometry , psychiatry , gene
Transient myeloproliferative disorder (TMD) and subsequent acute myeloid leukemia (AML) occur with increased frequency in infants and children with Down syndrome. TMD can also occur in phenotypically normal newborns. We describe the second case of a non‐Down syndrome child with TMD who subsequently developed AML. Trisomy 21 karyotype was restricted to hematopoietic cells in the blood and bone marrow. No other karyotypic abnormalities were found. Leukemic blasts showed megakaryoblastic features with immunophenotyping. This case shows that TMD in a child without Down syndrome may not be entirely benign. Close follow‐up is warranted. © 1994 Wiley‐Liss, Inc.