Premium
Increased glutathione in chronic lymphocytic leukemia lymphocytes
Author(s) -
Ferraris Anna Maria,
Rolfo Michela,
Mangerini Rosa,
Gaetani Gian Franco
Publication year - 1994
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830470318
Subject(s) - chronic lymphocytic leukemia , leukemia , immunology , medicine , glutathione , cancer research , chemistry , biochemistry , enzyme
Following reports on a variety of interactions between glutathione (GSH) concentration and clinical parameters in solid tumors, a study was undertaken in order to determine the GSH intracellular content of chronic lymphocytic leukemia (CLL) lymphocytes. The results from a group of 16 patients consecutively studied indicate that B‐CLL cells have twice as much GSH as lymphocytes from normal subjects, suggesting that this measurement may be helpful in the understanding of the metabolic mechanism of the disease and the rationale of therapy. © 1994 Wiley‐Liss, Inc.