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Ultrastructure of fibrillar granules in human neutrophils
Author(s) -
Takemori Nobuo,
Hirai Katsuyuki,
Onodera Ryuichi,
Saito Nagahito,
Miyokawa Naoyuki
Publication year - 1994
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830470316
Subject(s) - ultrastructure , actin , electron microscope , chemistry , bone marrow , biophysics , pathology , biology , microbiology and biotechnology , immunology , medicine , physics , optics
Fibrillar granules (FGs) represent neutrophilic primary granules containing clustered filaments. We investigated neutrophils in the bone marrow obtained from 17 patients with chronic myeloproliferative disorders (CMPD) by electron microscopy. FG‐positive neutrophils were seen in 15 of the 17 CMPDs with varying frequencies. The diameter of FG‐filaments was 7–8 nm, showing that they corresponded to neither intermediate filaments nor actin filaments. © 1994 Wiley‐Liss, Inc.