Rearrangement and expression of MDM 2  oncogene in chronic lymphocytic leukemia | Zendy

Huang Yao Qi | Zendy; Raphael Bruce | Zendy; Buchbinder Aby | Zendy; Li Jian Jun | Zendy; Zhang Wei Gue | Zendy; FriedmanKien Alvin E. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Rearrangement and expression of MDM 2 oncogene in chronic lymphocytic leukemia

Author(s) -

Huang Yao Qi,

Raphael Bruce,

Buchbinder Aby,

Li Jian Jun,

Zhang Wei Gue,

FriedmanKien Alvin E.

Publication year - 1994

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830470215

Subject(s) - chronic lymphocytic leukemia , pathogenesis , peripheral blood mononuclear cell , trisomy , biology , northern blot , cancer research , southern blot , leukemia , microbiology and biotechnology , chromosome , chromosome abnormality , gene , gene expression , immunology , genetics , karyotype , in vitro

Since trisomy 12 is the most common chromosome abnormality found in CLL and MDM 2 has been mapped to this chromosome, we examined the possible association of MDM 2 in the pathogenesis of CLL. A rearrangement of the MDM 2 gene was observed in 4 of 11 peripheral blood mononuclear cells (PBMC) from patients with CLL by Southern biot hybridization. Expression of MDM 2 was detected in all of the CLL samples examined by Northern blot. However, neither gross amplification nor overexpression of the MDM 2 gene was found in CLL. The data suggest that MDM 2 may play a role in the pathogenesis of CLL and may help to explain how abnormalities of chromosome 12 are related to CLL. © 1994 Wiley‐Liss, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research