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Differential expression of interleukin‐2 receptors (α and β chain) in mature lymphoid neoplasms
Author(s) -
Nakase Kazunori,
Kita Kenkichi,
Nasu Kaori,
Ueda Takanori,
Tanaka Isao,
Shirakawa Shigeru,
Tsudo Mitsuru
Publication year - 1994
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830460304
Subject(s) - receptor , immunology , biology , cancer research , medicine , genetics
We investigated the expression of interleukin‐2 receptors (IL‐2R) in 60 adult patients with mature lymphoid neoplasms by flow cytometric analysis, using two monoclonal antibodies, anti‐Tac for IL‐2R α‐chain (IL‐2Rα) and Mik‐β for IL‐2R β‐chain (IL‐2Rβ). Among B‐cell malignancies, IL‐2Rα was found in 13/25 (52%) cases of chronic lymphocytic leukemia (CLL) and its variants, 3/14 (21%) of a heterogenous group of non‐Hodgkin's lymphoma (NHL) and none of the plasma cell diseases. IL‐2Rβ was not observed in any of B‐cell neoplasms. IL‐2Rα was more frequently expressed in CD11 b(+) B‐cell neoplasms than in CD11b(‐) ( P < 0.05). In T‐cell disorders, all three cases of adult T‐cell leukemia/lymphoma expressed IL‐2Rα but not IL‐2Rβ. IL‐2Rβ was detected in 3/8 cases of CLL and 2/3 of NHL and none of these cases expressed IL‐2Rα. CD8(+) malignant T‐cells commonly displayed IL‐2Rβ. These data indicate that the IL‐2Rα and IL‐2Rβ in mature lymphoid neoplasms was expressed independently each other and was associated with the particular phenotypical characteristics of neoplastic cells, respectively. © 1994 Wiley‐Liss, Inc.