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Immune and serologic profiles of HIV‐infected and noninfected hemophilic children and adolescents
Author(s) -
Jason Janine,
Evatt Bruce,
Murphy John,
Sleeper Lynn A.,
Donfield Sharyne M.,
Warrier Indira,
Arkin Steven,
Gomperts Edward D.
Publication year - 1994
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830460106
Subject(s) - serology , immunology , medicine , antigen , antibody , measles , virology , vaccination
Objectives: To assess relationships among the effects of HIV on hemophilic children and adolescents' immunologic parameters and vaccine‐related serology. Methods: We analyzed data from extensive baseline immunologic evaluations of 207 HIV antibody‐positive (HIV+) and 126 HIV antibody‐negative (HIV−) hemophilic children and adolescents. Results: HIV+ and HIV‐ participants differed significantly in T‐lymphocyte subpopulation numbers, immunoglobulin levels, and seroprevalence rates for diphtheria toxoid, measles, and mumps antigens. IgG levels, IgM levels, and serologic titers to vaccine antigens showed little correlation with T‐cell parameters. Proportionately more HIV+ participants were nonreactive to each and all of a panel of 7 skin test antigens (71 % vs 28% anerglc, RR 2.6). The odds of anergy increased 1.6 times for every decline of 200 CD4 ± cells/μTl. Conclusions: HIV had significant, largely independent T‐ and B‐lymphocyte effects on this pediatric cohort. © 1994 Wiley‐Liss, Inc.