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Spontaneous factor VIII inhibitor occurring in association with chronic graft‐versus‐host disease
Author(s) -
Seidler Christopher W.,
Mills Letha E.,
Flowers Mary E. D.,
Sullivan Keith M.
Publication year - 1994
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830450309
Subject(s) - medicine , graft versus host disease , disease , immunology , risk factor , autoimmune disease , gastroenterology
The development of spontaneously acquired Factor VIII inhibitors is rare and may lead to serious hemorrhagic sequeiae. We report here the case of a patient who acquired a Factor VIII inhibitor two years after an allogeneic bone marrow transplant for CML. This occurred in association with a flare of chronic graft versus host dlsease (GVDH). He responded to corticosteroid therapy. A review of autoimmune phenomena associated with chronic GVDH and the treatment of Factor VIII Inhibitors is discussed. © 1994 Wiley‐Liss, Inc.