Spontaneous factor VIII inhibitor occurring in association with chronic graft‐versus‐host disease

The development of spontaneously acquired Factor VIII inhibitors is rare and may lead to serious hemorrhagic sequeiae. We report here the case of a patient who acquired a Factor VIII inhibitor two years after an allogeneic bone marrow transplant for CML. This occurred in association with a flare of chronic graft versus host dlsease (GVDH). He responded to corticosteroid therapy. A review of autoimmune phenomena associated with chronic GVDH and the treatment of Factor VIII Inhibitors is discussed. © 1994 Wiley‐Liss, Inc.