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Elevated plasma tissue factor antigen level in patients with disseminated intravascular coagulation
Author(s) -
Wada Hideo,
Nakase Tsutomu,
Nakaya Ryusuke,
Minamikawa Kouzou,
Wakita Yoshihiro,
Kaneko Toshihiro,
Ohiwa Michiaki,
Deguchi Katsumi,
Shirakawa Shigeru
Publication year - 1994
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830450307
Subject(s) - disseminated intravascular coagulation , tissue factor , medicine , coagulation , antigen , pathology , immunology
The plasma tissue factor (TF) antigen level was measured in patients with disseminated intravascular coagulation (DIC). The plasma TF antigen was detected In normal volunteers, and it was significantly higher in DIC patients than in non‐DiC patients. However, in some patients with DiC, the plasma TF antigen level was within the normal range. The plasma TF antigen level in patients with DIC significantly decreased after therapy, but it was not correlated with organ failure or outcome. The plasma TF antigen level in patients with DIC was not correlated with other hemostatic markers. The plasma TF antigen level tended to be higher in DIC patients with nonlymphoid leukemia than in those with lymphoid tumor. TF might be implicated in the occurrence and progression of DIC. © 1994 Wiley‐Liss, Inc.