Premium
Reversible encephalopathy after cryopreserved peripheral blood stem cell infusion
Author(s) -
Dhodapkar Madhav,
Goldberg Stuart L.,
Tefferi Ayalew,
Gertz Morse A.
Publication year - 1994
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830450218
Subject(s) - plasmapheresis , cryopreservation , peripheral blood stem cells , encephalopathy , medicine , toxicity , peripheral blood , stem cell , peripheral , anesthesia , surgery , gastroenterology , immunology , transplantation , biology , hematopoietic stem cell transplantation , embryo , genetics , antibody , microbiology and biotechnology
We report two patients who experienced severe reversible encephalopathy following infusion of peripheral blood stem cells cryopreserved in 10% dimethylsulfoxide (DMSO). In one patient, reduction of DMSO level with plasmapheresis resulted in marked improvement in encephalopathy. Infusion of large volumes of cryopreserved stem cells may result in a signiflcant toxlc reaction. Plasmapheresis may be a treatment option for patients with significant toxicity related to DMSO. © 1994 Wiley‐Liss, Inc.