Reversible encephalopathy after cryopreserved peripheral blood stem cell infusion | Zendy

Dhodapkar Madhav | Zendy; Goldberg Stuart L. | Zendy; Tefferi Ayalew | Zendy; Gertz Morse A. | Zendy

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Reversible encephalopathy after cryopreserved peripheral blood stem cell infusion

Author(s) -

Dhodapkar Madhav,

Goldberg Stuart L.,

Tefferi Ayalew,

Gertz Morse A.

Publication year - 1994

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830450218

Subject(s) - plasmapheresis , cryopreservation , peripheral blood stem cells , encephalopathy , medicine , toxicity , peripheral blood , stem cell , peripheral , anesthesia , surgery , gastroenterology , immunology , transplantation , biology , hematopoietic stem cell transplantation , embryo , genetics , antibody , microbiology and biotechnology

We report two patients who experienced severe reversible encephalopathy following infusion of peripheral blood stem cells cryopreserved in 10% dimethylsulfoxide (DMSO). In one patient, reduction of DMSO level with plasmapheresis resulted in marked improvement in encephalopathy. Infusion of large volumes of cryopreserved stem cells may result in a signiflcant toxlc reaction. Plasmapheresis may be a treatment option for patients with significant toxicity related to DMSO. © 1994 Wiley‐Liss, Inc.

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