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Production of parathyroid hormone‐related protein by cultured human myeloma cells
Author(s) -
Suzuki Akira,
Takahashi Takayuki,
Okuno Yoshiaki,
Tsuyuoka Reiko,
Sasaki Yutaka,
Fukumoto Manabu,
Katakami Hideki,
Kita Kenkichi,
Shibuya Tsunefumi
Publication year - 1994
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830450115
Subject(s) - parathyroid hormone , multiple myeloma , radioimmunoassay , parathyroid hormone related protein , myeloma protein , cell culture , medicine , messenger rna , endocrinology , bone marrow , biology , gene , calcium , biochemistry , genetics
We examined whether or not parathyroid hormone‐related protein (PTH‐rP) is produced in cultured human myeloma cells. PTH‐rP protein was detected in the cell extract of one (U266) of 6 myeloma cell lines examined by radioimmunoassay. Also we demonstrated the expression of PTH‐rP mRNA in all of the 6 lines. These findings indicate that PTH‐rP may be one of the factors responsible for the bone destruction or hypercalcemia in multiple myeloma. © 1994 Wiley‐Liss, Inc.