Production of parathyroid hormone‐related protein by cultured human myeloma cells | Zendy

Suzuki Akira | Zendy; Takahashi Takayuki | Zendy; Okuno Yoshiaki | Zendy; Tsuyuoka Reiko | Zendy; Sasaki Yutaka | Zendy; Fukumoto Manabu | Zendy; Katakami Hideki | Zendy; Kita Kenkichi | Zendy; Shibuya Tsunefumi | Zendy

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Production of parathyroid hormone‐related protein by cultured human myeloma cells

Author(s) -

Suzuki Akira,

Takahashi Takayuki,

Okuno Yoshiaki,

Tsuyuoka Reiko,

Sasaki Yutaka,

Fukumoto Manabu,

Katakami Hideki,

Kita Kenkichi,

Shibuya Tsunefumi

Publication year - 1994

Publication title -

american journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.456

H-Index - 105

eISSN - 1096-8652

pISSN - 0361-8609

DOI - 10.1002/ajh.2830450115

Subject(s) - parathyroid hormone , multiple myeloma , radioimmunoassay , parathyroid hormone related protein , myeloma protein , cell culture , medicine , messenger rna , endocrinology , bone marrow , biology , gene , calcium , biochemistry , genetics

We examined whether or not parathyroid hormone‐related protein (PTH‐rP) is produced in cultured human myeloma cells. PTH‐rP protein was detected in the cell extract of one (U266) of 6 myeloma cell lines examined by radioimmunoassay. Also we demonstrated the expression of PTH‐rP mRNA in all of the 6 lines. These findings indicate that PTH‐rP may be one of the factors responsible for the bone destruction or hypercalcemia in multiple myeloma. © 1994 Wiley‐Liss, Inc.

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