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Autoimmune‐thrombocytopenia and sle in a patient with 5q‐anomaly and deletion of the c‐fms oncogene
Author(s) -
Jaeger Ulrich,
Panzer Simon,
Bartram Claus,
Haas Oskar,
VolcPlatzer Beatrix,
Graninger Wolfgang,
Geissler Klaus,
Radaszkiewicz Thaddaeusz,
Lechner Klaus
Publication year - 1994
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830450112
Subject(s) - medicine , immunology , anti nuclear antibody , myelodysplastic syndromes , serology , autoimmune disease , concomitant , microchimerism , antibody , autoantibody , bone marrow , biology , genetics , pregnancy , fetus
Autoimmune‐thrombocytopenia was the striking feature in a patient with typical clinical symptoms of systemic lupus erythematosus (SLE), complement C 4 deficiency, and positive lupus serology. However, myelodysplasia was found in the bone marrow and chromosome analysis revealed a deletion of the long arm of chromosome 5 (5q‐ anomaly), which was confirmed by a hemitygosity for the c‐fms oncogene (CSF‐1‐receptor) on Southern blot. Autoimmune phenomena reported In conjunction with myelodysplastic syndromes (MDS), e.g., an elevation of antinuclear antibodies, are usually regarded as nonspecific. This case report suggests that SLE can occur in patients with MDS and that a concomitant autoimmune‐thrombocytopenia may mask the typical signs of the 5q‐ syndrome. © 1994 Wiley‐Liss, Inc.