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Elevated plasma levels of vascular endothelial cell markers in patients with hypercholesterolemia
Author(s) -
Wada Hideo,
Mori Yoshitaka,
Kaneko Toshihiro,
Wakita Yoshihiro,
Nakase Tutomu,
Minamikawa Kouzou,
Ohiwa Michiaki,
Tamaki Shigehisa,
Tanigawa Motoaki,
Kageyama Sinichi,
Deguchi Katsumi,
Nakano Takeshi,
Shirakawa Shigeru,
Suzuki Koji
Publication year - 1993
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830440208
Subject(s) - medicine , pravastatin , plasminogen activator , endocrinology , von willebrand factor , thrombomodulin , plasminogen activator inhibitor 1 , familial hypercholesterolemia , endothelial stem cell , fibrinolysis , vascular disease , tissue plasminogen activator , cholesterol , thrombin , platelet , chemistry , biochemistry , in vitro
Hypercholesterolemia is associated with an increased incidence of vascular complications. To assess the actual degree of activation of coagulation systems and vascular disorders in hypercholesterolemia, plasma levels of vascular endothelial cell markers, such as thrombomodulin (TM), tissue‐type plasminogen activator, plasminogen activator inhibitor‐l (PAl‐l), and von Willebrand factor, were measured in 51 patients with hypercholesterolemia. We also investigated the effects of Pravastatin, an inhibitor of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase, on plasma lipid, lipoprotein a, and hemostatic markers. The mean plasma levels of thrombin‐antithrombin III complex (TAT), fibrinopeptide A (FPA), TM, and PAl‐I were significantly elevated in hypercholesterolemia. Of the hemostatic markers, only TM was significantly increased in patients with ischemic heart diseases (IHD). The mean concentration of total cholesterol and levels of TAT, FPA, PAI‐I, and TM were significantly reduced after the Pravastatin treatment. The PIC/TAT ratio was significantly increased in non‐IHD patients after treatment, this was not the case in IHD patients. These findings suggested the presence of a thrombogenic state and vascular endothelial cell disorders in hypercholesterolemia; such a state might well be related to hypofibrinolysis. © 1993 Wiley‐Liss, Inc.