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Megakaryoblastic transformation of polycythemia vera associated with hypercalcemia
Author(s) -
Wong K. F.,
Chan J. K. C.,
Ma S. K.,
Chu Y. C.
Publication year - 1993
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830430317
Subject(s) - polycythemia vera , medicine , polycythemia rubra vera , transformation (genetics) , acute megakaryoblastic leukemia , myeloid leukemia , myeloid , immunology , biology , genetics , gene
Leukemic transformation is not uncommon in polycythemia vera, particularly after treatment with chemotherapeutic agents. The leukemias that supervene are mostly of myeloid type but megakaryoblastic transformation is distinctly uncommon. We report a case of polycythemia vera terminating in megakaryoblastic leukemia with associated hypercalcemia.