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Azidothymidine(AZT)‐induced siderosis
Author(s) -
Pollack Simeon,
Weaver Janet
Publication year - 1993
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830430314
Subject(s) - siderosis , zidovudine , medicine , superficial siderosis , virology , human immunodeficiency virus (hiv) , viral disease , disease , dementia , cerebral amyloid angiopathy
Azidothymidine(AZT) interferes with heme synthesis. This should upregulate the synthesis of transferrin receptors and increase the amount of iron taken up by the cell. We found a 50% increase in the iron content of liver and a 20% increase in the iron content of macrophages in AZT‐treated mice.