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Measurement of β 2 ‐glycoprotein i (apolipoprotein h)‐independent anticardiolipin antibody in human immunodeficiency virus‐1‐positive and‐negative hemophiliacs
Author(s) -
Matsuda Juzo,
Saitoh Noriko,
Tsukamoto Miyo,
Gohchi Kengo,
Asami Katsuhisa,
Hashimoto Masakatsu
Publication year - 1993
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830430215
Subject(s) - anticardiolipin antibodies , antibody , virology , glycoprotein , human immunodeficiency virus (hiv) , medicine , immunology , biology , microbiology and biotechnology
The authors studied whether or not anticardiolipin antibody (aCL), which is frequently detected in hemophiliacs with human immunodeficiency virus‐1 (HIV‐1) infection, is dependent on β 2 ‐glycoprotein I (GPI), a cofactor of cardiolipin (CL). GPI‐independent aCL was positive in 27 of 36 hemophiliacs with HIV‐1 antibody (75%) and in 23 of 29 patients without HIV‐1 antibody (79%). However, only six HIV‐1‐positive and four HIV‐1‐negative patients were positive for GPI‐dependent aCL. Thus the aCL in these hemophiliacs was GPI independent and therefore different from the aCL found in autoimmune diseases, such as systemic lupus erythematosus.