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The infusion of anti‐rho‐(D) opsonized erythrocytes may be useful in the treatment of patients, splenectomized or not, with chronic, refractory autoimmune thrombocytopenic purpura—a prospective study
Author(s) -
RuizArgüelles Guillermo J.,
AprezaMolina Maria Guadalupe,
PérezRomano Beatriz,
RuizArgüelles Alejandro
Publication year - 1993
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830430119
Subject(s) - thrombocytopenic purpura , refractory (planetary science) , medicine , opsonin , platelet , splenectomy , immunology , blockade , ex vivo , gastroenterology , in vivo , receptor , antibody , biology , spleen , microbiology and biotechnology , astrobiology
Six patients with chronic refractory autoimmune thrombocytopenic purpura (ATP) were treated with five doses of autologous red blood cells (RBCs) opsonized ex vivo with anti‐RhO‐(D) IgG. Increases in platelet counts were observed in all cases; complete responses requiring no further treatment—for periods of 8–72 months—were recorded in four patients, three of them splenectomized. The cost of the procedure was significantly lower than other 'Fc receptor (FcR) blockade' treatments.