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Polycythemia associated with primary systemic amyloidosis: Elevated levels of hemopoietic factors and cytokines
Author(s) -
Nagasawa Toshiro,
Yanagisawa Hiromi,
Hasegawa Yuichi,
Kanma Hiroshi,
Abe Tsukasa
Publication year - 1993
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830430114
Subject(s) - haematopoiesis , erythropoietin , amyloidosis , granulocyte colony stimulating factor , colony stimulating factor , stem cell , medicine , immunology , biology , genetics , chemotherapy
A 60‐year‐old man was diagnosed to have primary systemic amyloidosis (AL type) and polycythemia (Hgb 19.1 g/dl, WBC 14,600/μl, and platelets 60.5 × 10 4 /μl). In vitro colony assay for hemopoietic stem cells showed increased numbers of colony‐forming units (CFU)‐G, CFU‐GM, CFU‐E, and CFU‐Meg. Serum levels of erythropoietin (Epo), granulocyte colony‐stimulating factor (G‐CSF), interleukin (IL)‐3 and IL‐6 were elevated. The infiltration of amyloid fibrils into the hemopoietic factor‐producing tissues may stimulate abnormal secretion of hemopoietic factors and cytokines, resulting in increased numbers of hemopoietic stem cells and polycythemia in the peripheral blood.