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New translocation involving homologous chromosome 3 in acute myelogenous leukemia (M2)
Author(s) -
Verma Ram S.,
da Costa Maria,
Gogineni Swarna K.,
Palermo Giuseppe
Publication year - 1993
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/ajh.2830420414
Subject(s) - chromosomal translocation , homologous chromosome , leukemia , chromosome , philadelphia chromosome , medicine , genetics , biology , gene
An apparent balanced translocation involving the long arms of homologous chromosomes is described for the first time in a patient with acute myelogenous leukemia (AML) (M2), i.e., 46, XY, t(3;3) (q21;q26). After reviewing the literature, it was noted that a breakpoint involving band 3q26 is a frequent anomaly in other translocations. Thus, we are tempted to hypothesize that 3q26 band may also play an important role in the pathogenesis of AML (M2). © 1993 Wiley‐Liss, Inc.